The MERLIN consortium has published a joint-article in Scientific Reports (open access). The article describes the novel retinal imaging device developed in the project, its architecture and imaging capabilities. It includes images obtained on healthy and diseased eyes.
- Shirazi, M. F., Andilla, J., Lefaudeux, N., Valdes, C., Schwarzhans, F., Durand, M., Ntatsis, K., De Jesus, D. A., Sanchez Brea, L., Gocho, K., Gautier, J., Eckmann-Hansen, C., Torm, M. E. W., Amini, A., Klein, S., Van Walsum, T., Grieve, K., Paques, M., Larsen, M., … Pircher, M. (2022).
Multi-modal and multi-scale clinical retinal imaging system with pupil and retinal tracking.
Scientific Reports, 12(1), 9577. https://doi.org/10.1038/s41598-022-13631-1
Abstract: We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCTA) imaging modalities and provides multi-scale fields of view. For high resolution, and high lateral resolution in particular, cellular imaging correction of aberrations by adaptive optics (AO) is employed. The entire instrument has a compact design and the scanning head is mounted on motorized translation stages that enable 3D self-alignment with respect to the subject’s eye by tracking the pupil position. Retinal tracking, based on the information provided by SLO, is incorporated in the instrument to compensate for retinal motion during OCT imaging. The imaging capabilities of the multi-modal and multi-scale instrument were tested by imaging healthy volunteers and patients.