MERLIN almost ready for clinical validation

As the design of the MERLIN instrument is complete, the project enters a very exciting phase.

A first prototype unit, fully integrated and equipped with a graphic user interface, has passed safety tests successfully. It delivers OCT, SLO, AO-OCT and AO-SLO images.

After final calibration, Imagine Eyes will transfer this MERLIN unit to the Quinze Vingts National Eye Hospital in Paris. One month later, a second prototype will arrive at the Rigshospitalet in Copenhagen. Clinical validation with  these two sites will then begin.

The collaborative efforts on designing the instrument do not stop with its transfer to the clinical partners. Indeed, the technical partners will continue their developments, to implement improvements and additional functionalities over the course of the clinical validation.



Clinicians try the MERLIN instrument at Imagine Eyes

MERLIN project members from Quinze-Vingts Eye Hospital visited Imagine Eyes last week. For the first time, they could use the MERLIN instrument, in its R&D version.

The optical head did not have a cover, and it was not installed on medical-grade furniture. However the graphic user interface was already implemented. Thanks to that, the clinicians could acquire large field images and then easily zoom on regions of interest using the adaptive optics scan modes.

This first experience with the unfinished prototype was very promising. Engineers in observation felt the clincians’ excitement, and they could collect feedback very useful for next developments.




Dissemination at the i2Eye meeting

On October 12-14, the Innovative Imaging for Eye Disease conference (i2Eye) gathered a hundred speakers and attendees from Europe and North America. 

Several speakers presented about multimodal retinal imaging as well as cellular and microvascular imaging using adaptive optics technology. They showed how it enables further understanding diseases such as age-related macular degeneration and retinitis pigmentosa, and help improve clinical care.

For those who missed i2Eye 2020, the program as well as video recordings are available on this page.


Innovative Imaging in Eye Disease meeting organized by MERLIN partner

MERLIN project partners Kate Greive and Michel Paques organize their third Autumn course on Innovative Imaging in Eye Disease, the i²Eye 2020 meeting. The conference will be held online, on October 12-14, 2020.

Abstract submission and free registration open here
Abstract deadline: September 4th

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New MERLIN members

INSERM, the National Institute of Health and Medical Research, hired Dr Kiyoko Gocho, ophthalmologist and medical researcher, as well as Dr Josselin Gautier, postdoctoral researcher. They will work on the clinical evaluation of the MERLIN device at the Quinze-Vingts National Eye Hospital.

ARVO presentations by MERLIN partners

The MERLIN partners had 5 presentations planned at the ARVO Annual Meeting and Imaging in the Eye Conference 2020. Abstracts are published in the IOVS journal, a video presentation is also available on ARVO Learn.


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Impressive AO SLO images by MERLIN

Adaptive optics correction system has been integrated in the MERLIN device. It delivers AO-SLO images that enable to observe the retina with unprecedented level of details: the cellular level.

The following images were captured on healthy eyes. On each image, the structures observed are only a few micron in size.

  • top image: individual visual cells (photoreceptor cones)
  • middle image: more individual visual cells (photoreceptor cones and rods)
  • bottom image: structure of blood vessels (artery in the corner, capillaries in the middle) as well as white cells (gunn dots).


ICFO’s new recruit

ICFO, the Institute of Photonics and Sciences, hired Dr. Claudia P. Valdés E. as postdoctoral researcher to work on the MERLIN project.

Stunning SLO images by MERLIN

The integration of the MERLIN device keeps on progressing, and it delivered stunning SLO images. The infrared pictures below are from a healthy eye (top) and a pathological eye (bottom).

First OCT images by MERLIN

As the integration of the MERLIN device is progressing, it delivered its first OCT images. The high quality B-scans below are from a healthy eye (top) and a pathological eye (bottom).